PHSYC 643-Psychopharm.MODULE 5(DEPRESSION)latest 2020
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Study Guide Module 5: Depression
Familiarize yourself with theories of bipolar spectrum disorder and their criticism (Article: Bipolar Spectrum: A Critical Perspective) with consideration of the following:
1. Patient presentation rarely fits neatly into unipolar depression, bipolar I and bipolar II diagnostic criteria.
2. Treatment decisions can be guided by the bipolar spectrum classification.
What are the 3 neurotransmitters most implicated in mood disorders?
Serotonin, Dopamine, Norepinephrine
Describe the synthesis of norepinephrine.
Tyrosine Hydroxylase convert amino acid Tyrosine into DOPA, DOPA decarboxylase convert DOPA to DA, Dopamine b hydroxylase converts DA into NE
How is norepinephrine metabolized?
Monoamine oxidase (MAO) A or B, Catechol-o-methyl-transferase (COMT)
What is the significance of presynaptic alpha-2 receptors?
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PHSYC 643-Psychopharm.MODULE 5(DEPRESSION)latest 2020
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