Review -in-Partnership-Corporation Myc

MYC is a family of regulator genes and proto-oncogenes which code for transcription factors. In human genome, C-MYC is at chromosome 8 and it regulates expression of 15% of all genes through binding on enhancer box sequences. MYC as initiator of tumorigenesis • The MYC oncogene contributes to the beginning of many human cancers. Recent insights into its expression and function have led to cancer therapeutic opportunities which are new. • MYC’s activation by bromodomain proteins can be inhibited by drug-like molecules, hence resulting in tumor inhibition in vivo. Tumor growth can be curbed by pharmacologically uncoupling bioenergetic pathways which involve glutamine metabolism from Myc-induced cellular biomass accumulation. • Other ways to halt Myc on the path to cancer include targeting Myc-Max dimerization or Myc-induced microRNA expression. • MYC is a potent oncogenes as measured in vitro and in vivo assays for cell transformation phenotypes. MYC activation alone cannot induce tumorigenesis. • When MYC was first observed to induce neoplastic transformation, this was detected in specific cell lines that were presumed to have acquired other genetic events which rendered them permissive. • Although it is a commonly activated oncogene...

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