NR565/NR 565 ADVANCED PHARMACOLOGY  CARE OF FUNDAMENTALS MIDTERM  EXAM WITH VERIFIED ANSWERS

NR565/NR 565 ADVANCED PHARMACOLOGY CARE OF FUNDAMENTALS MIDTERM EXAM WITH VERIFIED ANSWERS QUESTION How does strength of fentanyl compare to morphine Answer: high milligram potency (about 100 times that of morphine) QUESTION through what system is fentanyl metabolized? Answer: CYP34A (isoenzyme of CYP450), levels of fentanyl can be increased by CYP34A inhibitors QUESTION What is methadone used to treat? Answer: relieve pain and treat opioid addiction QUESTION What are some things that put the elderly patient at higher risk for adverse drug reactions? Answer: reduced renal function polypharmacy (the use of five or more medications daily) greater severity of illness presence of comorbidities use of drugs that have a low therapeutic index (e.g., digoxin) increased individual variation secondary to altered pharmacokinetics inadequate supervision of long-term therapy poor patient adherence QUESTION How can healthcare providers decrease likelihood of an elderly patient experiencing an adverse drug reaction? Answer: obtaining a thorough drug histor...

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