NURS_615_week_4_Nervous_System_Case_Study.docx NURS 615 Fluoxetine Medication Maryville

NURS_615_week_4_Nervous_System_Case_Study.docx  NURS 615  Fluoxetine Medication  Maryville University  Drug Action and Use  Fluoxetine (Prozac) is a selective serotonin reuptake inhibitor (SSRI). It blocks the absorption of the neurotransmitter serotonin in the brain and from it returning remaining serotonin to presynaptic cells (Woo & Robinson, 2016).  This helps the regulate the amount of serotonin that each brain cell can transmit to each other (“Fluoxetine: MedlinePlus Drug Information,” 2019) by blocking the reuptake of serotonin. The active metabolite is norfluoxetine, this is produced when CYP 450 enzymes act on it and its important to remember that many of the drug-to drug interactions can occur because of the metabolism at the CYP2D6 isoenzyme.  Prozac is an antidepressant that is used to treat depression, in hopes to produce a more stable mood for someone. It is used to treat more than depression, you will see it used for obsessive-compulsive disorder, and panic disorder, and bulimia. (Sohel, Shutter, & Molla, 2019). More recently there have been some off labeling uses for Prozac (Fluoxetine) that include social anxiety disorder, post-traumatic stress disorder in adults, borderline personality disorder, chronic headaches (Woo & Robinson, 2016). Further research will need to be done to support the continued use of Prozac for these disorders.  Drug Absorption, Metabolism, Distribution and Excretion  Fluoxetine is given orally and completely absorbed in the GI tract. They are highly protein bound and have varyin