A3ADVANCEDPATHO.docx Gastrointestinal Tract: Disorder of Motility Walden University A

A3ADVANCEDPATHO.docx    Gastrointestinal Tract: Disorder of Motility  Walden University  Advanced Pathophysiology  Gastrointestinal Tract: Disorder of Motility  Introduction  It is interesting to know that some medications, age, certain behaviors and chronic medical conditions can predispose a person to have hypersecretion of gastric acid that can lead to stomach disorders.  Oversecretion of gastric acid increases the risk for peptic ulcer disease, GERD and gastrointestinal bleeding, not to mention an increase in the mortality and morbidity to these conditions (Phan, Benhammou, & Pisegna, 2015).  In the United States, diseases related to gastric acid account for nearly one third of all healthcare spending  on GI diseases (Kumar, Abbas, Fausto, & Aster, 2010).  Gastric acid secretion is regulated by the hormone gastrin; hypergastrinemia is an important diagnostic indicator of the level of gastric secretion (Phan et al., 2015).  This paper will discuss the normal pathophysiology of gastric acid stimulation and production with GERD, PUD and gastritis disorders.  Furthermore, it will elaborate on how  age and behavior play an important role in the pathophysiology of GERD,  peptic ulcer disease and gastritis.  Normal Gastric Stimulation and Production  Gastric acid aids in digestion by creating the optimal pH for pepsin and gastric lipase and by stimulating pancreatic bicarbonate secretion (Vakil, 2018).  Gastric glands in the corpus of the stomach contains parietal cells which secretes HCl,