Week 5 ATI report and analysis.docx NR 293 Administration of Alteplase to Combat a Strok

Week 5 ATI report and analysis.docx  NR 293  Administration of Alteplase to Combat a Stroke  Chamberlain College of Nursing   NR 293 “ Pharmacology   Alteplase is a thrombolytic agent approved for pulmonary embolism, myocardial infarction, and ischemic stroke (Reed, Kerndt, & Nicolas, 2020). Alteplase is also known as a tissue plasminogen activator, tPA. The way tPA works due to plasminogen converting to plasmin; this results in a lysis formation. Alteplase is only available in an IV form. The administration starts by giving a bolus of 10% of the total dose over one minute, then the remaining amount id administered over the next 60 minutes (Reed, Kerndt, & Nicolas, 2020). To be most effective, the patient needs to receive this medication as soon as possible and needs to be within 3 “ 4.5 hours of the onset of symptoms. Before administration, blood work should be taken, including a CBC, aPTT, and a serum fibrinogen test; the