ATI PHARMACOLOGY PROCTORED STUDY GUIDE - STUDY QUESTIONS & ANSWERS

ATI PHARMACOLOGY PROCTORED STUDY GUIDE
QUESTIONS & ANSWERS
The pKa (for the COOH group) of each of the three drugs is as follows:
thyroxine = 3.0,
mesothyroxine = 4.0,
neothyroxine = 5.0.
Of these, which will be absorbed to the greatest extent from the stomach (pH = 1.0)?
neothyroxine

2. The multi drug resistance proteins (or p-glycoproteins) can protect liver and kidney cells by exporting harmful chemicals against a concentration gradient in an energy-dependent manner. What is this called?
active transport

3. Phase II conjugates typically have the following property/properties
rapidly excreted in the urine

4. A drug with a half-life of 2 hours is administered by continuous intravenous infusion. How long will
it take for the drug to reach 50% of its steady state concentration?
2 hours